A growing body of research is exploring ways to slow, or even reverse, aspects of the aging process — and a leading neuroscientist has highlighted three supplements that show promising effects on brain health, longevity, and cellular rejuvenation. While no supplement is a magic cure, experts say these compounds may support the body’s natural repair mechanisms when combined with a healthy lifestyle.
1. Nicotinamide Mononucleotide (NMN)
NMN is a precursor to NAD+, a molecule crucial for cellular energy production and DNA repair. Studies suggest that boosting NAD+ levels may enhance mitochondrial function, improve cognitive performance, and support overall metabolic health. According to neuroscientists, NMN supplementation may help maintain youthful cellular activity, potentially slowing age-related decline in tissues, including the brain.
2. Resveratrol
Found naturally in grapes, berries, and red wine, resveratrol is a polyphenol with antioxidant and anti-inflammatory properties. Research indicates that it may activate certain longevity pathways, including SIRT1, which helps regulate cellular health and repair. Neuroscientists highlight its potential to protect neurons, improve blood flow to the brain, and mitigate oxidative stress associated with aging.
3. Fisetin
Fisetin is a flavonoid present in strawberries, apples, and cucumbers that has gained attention for its senolytic properties — the ability to target and clear senescent cells. These “zombie” cells accumulate with age, contributing to inflammation and tissue deterioration. By reducing the burden of senescent cells, fisetin may support organ function, enhance cognitive clarity, and improve overall vitality.
Caution and Expert Advice:
While these supplements show promise in laboratory and early human studies, neuroscientists emphasize that results may vary, and long-term effects are still under investigation. Supplements should complement, not replace, a healthy diet, regular exercise, adequate sleep, and stress management. Consulting a healthcare professional before beginning any regimen is essential, especially for individuals with underlying medical conditions or those taking prescription medications.
As science advances, these compounds may form part of a broader strategy to enhance healthy aging and preserve cognitive function, offering hope for extending both lifespan and quality of life.
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